产品编号
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包装
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价格
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3710026-N
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0.5mg
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680.00
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3710026-N1
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1mg
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1280.00
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3710026-N2
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2mg
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1980.00
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产品简介
Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus.Following IKK-mediated phosphorylation of p105 NF-κB at multiple sites (Ser921, 923, 927, and 932) on its carboxy-terminus, SCF/β-TrCP mediated processing produces the 50 kDa active form p50.
NF-κB1多肽(NF-κB1 Polypeptide)为本所人工合成并纯化的NF-κB1的多肽片段,本品为干粉或水溶液。
包装
产品编号
|
3710026-N
|
3710026-N1
|
3710026-N2
|
NF-κB1多肽
|
0.5mg
|
1mg
|
2mg
|
说明书
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1 份
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保存
在-20℃或以下可保存1年或以上。使用过程中可短时间保存于4℃。请勿反复冻融或于0℃以上久置。
更新时间:2016-05-12 浏览次数:940次
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